Student Theses and Dissertations

 

The Rockefeller University has awarded over one thousand Ph.D’s since 1959. This collection contains theses beginning with the graduating class of 2006. Earlier theses are added by request or as permission to digitize is received. For more information visit the FAQ page.

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2023

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A Gain-of-Function Role of Apolipoprotein E2 in Melanoma Progression, Nneoma Adaku

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The Search for Regulatory Mutations in Gitelman Syndrome, Renan Eduardo Aparicio

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Replaying Life's Tape With Intraclonal Germinal Center Evolution, Tatsuya Araki

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Development of Improved Genetic Methods for Enterococcus Faecium, Victor Chen

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Interrogation and Manipulation of the IGG FC Glycan, Aaron Keshav Gupta

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Transgenic Tools in Ants and the Representation of Alarm Pheromones in the Ant Antennial Lobe, Taylor Eco Hart

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Cortical Control of Naturalistic Facial Expression Production in Primates, Geena Rose Ianni

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Neural Control of Sickness Behavior, Anoj Ilanges

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Antibody-Effector Functions in Antiviral Response, Kevin Shuolong Kao

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Using Chemical Probes to Examine Cellular Activities, Megan Elizabeth Kelley

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Rarely Acquired Type II-A CRISPR-Cas Spacers Mediate Anti-Viral Immunity Through the Targeting of a Non-Canonical PAM Sequence, Claire T. Kenney

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Sex Differences and the Evolution of Gene Expression, Samuel Khodursky

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Neotelomere Formation by Telomerase in Human Cells, Charles Gunnar Kinzig

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Multiplexed Mapping of the Interactome of G Protein-Coupled Receptors and Receptor Activity-Modifying Proteins, Ilana Beth Kotliar

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Structures, Functions, and Druggability of the SARS-CoV-2 Replication–Transcription Complex, Brandon F. Malone

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On the High-Dimensional Geometry of Neuronal Population Dynamics, Jason M. Manley

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Bioorthogonal Tethering of Drug Fragments to Engineered G Protein-Coupled Receptors, Jordan M. Mattheisen

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Mechanical Manipulation of Eukaryotic Chromatin by DNA-Binding Proteins, Tuan Nguyen

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Structural and Functional Analysis of Substrate Recognition and Inhibition of the Multidrug Transporters MRP1 and MRP2, Harlan Linver Pietz

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Converting an Allocentric Goal Direction into an Egocentric Steering Signal in Drosophila, Peter Mussells Pires

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Dissecting Host-Viral Interactons Through Focused or Unbiased High-Throughput Genetic Approaches, Daniel Poston

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A Chemical-Genetic Map of Drug Resistance in Mycobacterium Tuberculosis, Nicholas Poulton

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Deep Molecular Characterization of Human Cortical Cell-Types, Christina Pressl

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Inter-Organellar Nucleic Acid Communication by a Mitochondrial tRNA Regulates Nuclear Transcription, Christopher Rouya

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Life on the Edge: Insights into the Neural and Behavioral Algorithms of Plume Tracking, Andrew Siliciano

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The Internal Orchestration of a Courtship Ritual in Drosophila, Tom Anton Hindmarsh Sten

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Anteromedial Thalamus Gates the Selection & Stabilization of Long-Term Memories, Andrew Toader

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Life on a Ball: Multi-Week Tethered Behavior in Drosophila, Jazz Weisman

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Enrichment and Transcriptome Analysis of CD4+ T Cell Clones Harboring Intact HIV-1 Proviruses, Georg Hartmut Johannes Weymar

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On the Origins of Genetic Novelty in Drosophila, Eric Bo Zheng

2022

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Human Antibody Response to Flaviviruses and SARS-Coronavirus-2, Marianna Elizabeth Agudelo

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The Effect of Early Dietary Intervention on Alzheimer's Disease-Related Pathology and Cognitive Function in Mice, Anna Amelianchik

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The Genetic and Neural Basis of Sexual Dimorphism in Mosquito Behavior, Nipun Basrur

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B Cell Receptor Signalng in Germinal Centers, Spencer T. Chen

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Uncovering Regulators of Whole-Body Metabolism by Chemoproteomic Profiling of the Adipocyte Secretome, Chan Hee J Choi

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Novel Optical Tools to Investigate Presenilin Control of Neurotransmission, Ryan J. Farrell

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Songbird Brain Organization and its Molecular Convergence with Humans for Vocal Imitation Learning, Gregory Gedman

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Non-Canonical Odor Coding Ensures Robust Mosquito Attraction to Humans, Margaret Herre

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Biased Constitutive Activity in the Uveal Melanoma Oncogene CYSLTR2 is Unique in CYSLTR2 Germline and Pan-Cancer Human Variome, Mizuho Horioka-Duplix

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Integration Sites in the Persistence of Latent HIV-1, Amy S. Huang

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New Roles for the Integrated Stress Response in Cancer and Proteostasis, Brian Hurwitz

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DNA Methylation and DNA Methyltransferases in the Clonal Raider Ant, Ooceraea biroi, Ivasyk Iryna

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Sign-Inverting Vectors Underlie a Coordinate Transformation in the Drosophila Central Brain, Itzel Gonzalez Ishida

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Structure and Mechanism of PCAT1, a Polypeptide Processing and Secretion Transporter, Virapat Kieuvongngam

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Nonlinear Representation of Auditory Stimuli Across the Auditory Cortex, Frank Tejera Leon

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Intestinal CD4+T Cell Responses to Food, Ainsley Lockhart

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Building an Allocentric Traveling-Direction Signal Via Vector Computation, Cheng Lyu

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Restriction-Modification and CRISPR-Cas Systems: Cooperation Between Innate and Adaptive Immunity in Prokaryotes, Pascal Maguin

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Peptidergic Signaling Controls the Dynamics of Sickness Behavior in Caenorhabditis Elegans, Javier Marquina-Solis

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Multi-Modal Regualtion of Actin Networks, Lin Mei

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Structural Studies of the Nucleolar Stages of Ribosome Biogenesis in Yeast, Linamarie Miller

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53BP1/Shieldin Counteract DSB Resection Through Fill-In Synthesis, Zachary Kenneth Mirman

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Tumor Suppression by a TRNA Synthetase, Maria Passarelli

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A Developmental Pathway for Epithelial-to-Motoneuron Transformation in C. Elegans, Alina Rashid

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Modulation of Prefrontal Cortex activity and sociability by local interneurons expressing corticotropi-releasing hormone, Michael Riad

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Sensory and Neuromodulatory Entrainment of Foraging States in C. Elegans, Elias Scheer

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Characterization of a Novel Sensing Mechanism Governing Antigenic Variation in P. Falciparum, Victoria M. Schneider

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Transcriptomic and Proteomic Studies of Intercellular Communication Between Melanocytes and Keratinocytes in Human Skin, Gabriella Stephanne Spitz-Becker

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Reproductive Resilience of Aedes aegypti Mosquitoes, Krithika Venkataraman

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Reproductive Resilience of Aedes Aegypti Mosquitoes, Krithika Venkataraman

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Endogenous Neurosteroid Hormone Production and Early Oligodendricyte Development, Paige Winokur

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Ultra-Fast and Multi-Dimensional Face Processing in a New Face Area, Zetian Yang

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Mechanistic Understanding of the Role of TRF1 in Telomere Replication, Zhe Yang

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Ras Drives Malignancy Through Stem Cell Crosstalk with the Microenvironment, Shaopeng Yuan

2021

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Metabolic Coordination of Stem Cell Fate Controls Tumor Initiation and Tissue Repair, Sanjeethan C. Baksh

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Restriction of Food Intake by Dorsomedial Hypothalamus, Caner Caglar

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Cerebral Amyloid Angiopathy-Causing Beta-Amyloid Variants Have Altered Effects on the Clotting System, Steven Cajamarca

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Mechanisms for the Evolution of Superorganismality in Ants, Vikram Chandra

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Non-Canonical Axonal Insulin Receptor signaling Drives Aversive Olfactory Learning, Du Cheng

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Unraveling the Interaction Between Beige Adipocytes and the Sympathetic Nervous System, Jingyi Chi

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Linker Histone Medicated Regulation of Mitotic Chromosome Compaction and Individualization, Pavan Choppakatla

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Brochemical Studies of Peptidoglycan Hydrolases from Commensal and Pathogenic Bacteria, Juliel Espinosa

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Finding Common Ground: The Common Marmoset as a Model to Accessing and Providing Insight into the Social Brain, Margaret Fabiszak

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Tension Propagation Along Tip-Link Cadherins: Regulation and Implications for the Auditory System, Daniel M. Firester

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Deciphering Cancer Metabolic Dependencies in the Tumor Microenvironment, Xiphias Ge Zhu

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The Role of DNA Methylation in Defining the Vocal Learning Transcriptome of the Zebra Finch, Caitlin Sun Gilbert

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The Role of Nutrient Availability in Therapeutic Response of Leukemia, Rohiverth Guarecuco Jr

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Not Black and White: BMP Signaling Drives Melanocyte Differentiation Down Stream of Stem Cell Activation, Nicole Rai Infarinato

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The Taste of Blood, Veronica Jove

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Single-Molecule Investigation of Chromatin-Associated Factors in Genome Organization and Epigenetic Maintenance, Rachel Leicher

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Pathogenic Characterization and Therapeutic Development for Fiblrolamellar Hepatocellular Carcinoma, Solomon N. Levin

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Structural Study of Disease Relevant ABC Transporters-Cystic Fibrosis Transmembrane Conductance Regulator and ABCA4, Fangyu Liu

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A Role for ACSBG1 in Obesity-Accelerated Breast, Olivia Maguire

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Interactions Between Microbial, Neuronal, and Immune Cells in the Digestive System, Fanny Matheis

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Genome-Wide Human-Specific RNA Regulatory Elements in the Brain, Elisabeth A. Murphy

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Characterizing Inflammatory Mechanisms in Hidradenitis Suppurativa, Kristina Navrazhina

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Noggin Transport in a Model Human Epiblast, Tiên Phan-Everson

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Accessory Nucleases Provide Robust Antiparasite Immunity for Type III CRISPR-Cas Systems, Jakob Træland Rostøl

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A Proteomic Approach to Elucidating the Function of Picornavirus 2A Protease, Artem Serganov

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A Translational Approach to Modeling Unique Aspects of Germ Cell Development During Self-Organization of the Primate Embryo, Rohan R. Soman

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Developmental Dynamics of 5-Hydroxymethylcytosine and its Role in the Terminal Differentiation of Neurons, Elitsa Stoyanova

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A-to-I RNA Editing in Human Cells, Tony Sun

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Chemical Tools for Exploring Metabolite Interactions with Nuclear Receptors and Beyond, Taku Tsukidate

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The Identification of a Leptin Dependent Neural Pathway Regulating Adipose Tissue Innervation, Putianqi Wang

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Quantifying the Release of Protein Substrates from AAA+ ATPase ClpX by Single Molecule Total Internal Reflection Fluorescence Microscopy, Xiao Wang

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The Role of Compartmentalized Metabolism in Cellular Metal Homeostasis, Ross A. Weber

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Transcriptional Regulation of the Metabolic Response to Therapy in Leukemia, Robert Thomas Williams

2020

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The Role of Adipocytes in the Tumor Microenvironment in Obesity-Driven Breast Cancer Progression, Sarah Ackerman

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Blood-Derived Plasminogen Modulates the Neuroimmune Response in Both Alzheimer's Disease and Systemic Infection Models, Sarah K. Baker

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Characterizing the RNA Editing Specificityof ADAR Isoforms and Deaminase Domains In Vitro, Mariel Therese Bartley