Neural Population Dynamics Underlying Encoding of Time in the Cortico-Striatal Circuit

Author

Francisca Martínez Traub

Date of Award

2023

Document Type

Thesis

Degree Name

Doctor of Philosophy (PhD)

Abstract

Interval timing, the ability to accurately measure elapsed time between events, is critical for generating appropriate behavioral responses. Research conducted over the past decades has implicated the cortico-striatal-thalamic loop in time encoding,suggesting that the cortex utilizes high-dimensional dynamics to represent time. The dorsal lateral region of the striatum (dlSt) is a key structure involved in interval timing,where neurons exhibit dynamic firing rate patterns that encode elapsed time, enabling animals to make perceptual judgments about time intervals. However, it is unlikely that this striatal activity is self-generated, pointing towards cortical afferent inputs as the driving force behind it.

Comments

A Thesis Presented to the Faculty of The Rockefeller University in Partial Fulfillment of the Requirements for the degree of Doctor of Philosophy

Recommended Citation

Traub, Francisca Martínez, "Neural Population Dynamics Underlying Encoding of Time in the Cortico-Striatal Circuit" (2023). Student Theses and Dissertations. 768.
https://digitalcommons.rockefeller.edu/student_theses_and_dissertations/768