Use of Genetically Encoded Tools to Interrogate Mechanisms of Glutathione Homeostasis from Mitochondria to Mice

Author

Rebecca Timson

Date of Award

2024

Document Type

Thesis

Degree Name

Doctor of Philosophy (PhD)

RU Laboratory

Birsoy Laboratory

Abstract

Glutathione is an evolutionarily ancient molecule that underlies many critical biological processes across all categories of life.It acts as a cofactor in some metabolic reactions,modifies proteins to modulate their activity, and participates in detoxification of xenobiotic compounds.Despite these wide-ranging functions, glutathione is best known as an antioxidant.Some consider it akin to the fountain of youth because it decreases throughout the course of aging while oxidative damage accumulates.In addition to aging,glutathione dysregulation occurs in a plethora of diseases, including neurodegenerative diseases like Alzheimer’s and Parkinson’s Disease, liver disease, and metabolic disease,among others.

Comments

A Thesis Presented to the Faculty of The Rockefeller University in Partial Fulfillment of the Requirements for the degree of Doctor of Philosophy

Recommended Citation

Timson, Rebecca, "Use of Genetically Encoded Tools to Interrogate Mechanisms of Glutathione Homeostasis from Mitochondria to Mice" (2024). Student Theses and Dissertations. 785.
https://digitalcommons.rockefeller.edu/student_theses_and_dissertations/785