Student Theses and Dissertations

 

The Rockefeller University has awarded over one thousand Ph.D’s since 1959. This collection contains theses beginning with the graduating class of 2006. Earlier theses are added by request or as permission to digitize is received. For more information visit the FAQ page.

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2015

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Mechanical Control of Sensory Hair-Bundle Function, Joshua D. Salvi

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Activity Based Profiling: New Insights into Metabolic Homeostasis, Keith Tan

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Xenopus DPPA2 is a Direct Inhibitor of Microtubule Polymerization Required for Nuclear Assembly, John Zhao Xue

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Neural Circuit Dependence of Acute and Subacute Nociception in C. Elegans, Yifan Xu

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A New Role for Beta-Amyloid in Alzheimer's Disease: Initiation of Thrombotic and Inflammatory Processes Via Coagulation Factor XII and Fibrinogen, Daria Zamolodchikov

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Components of the Ubiquitin Proteasome System are Required for the Nonapoptotic Death of the C. Elegans Linker Cell, Jennifer Zuckerman Malin

2014

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Abdominal-B Neurons Control Drosophila Virgin Female Receptivity, Jennifer J. Bussell

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Stochastic Activation of Enhancers in the Innate Immune Response by the Histone Demethylase JMJD2D, Rohit Chandwani

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Coordinating Stem Cell Behavior in the Hair Follicle, Chiung-Ying Chang

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Taming a Potent Mutator: Identification and Characterization of Novel Mechanisms of Regulating Antibody Diversification in B-Lymphocytes, Rebecca Kyle Delker

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Genome-Wide Characterization of the Effects of Nucleic Acid Modifying Enzymes: Cytidine Deaminases and DNA Methylation, Eric Luke Fritz

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Mutations in a Mechanosensitive Channel Enable Intravascular Metaststic Cell Survival, Paul William Furlow

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Studies of a Novel Phage Lytic Enzyme, PlySs2, Daniel B. Gilmer

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Transcriptome-Wide Characterization of APOBEC1-Catalyzed RNA Editing Events in Macrophages, Claire Ellen Hamilton

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Forces Generated by Cell Intercalculation Tow Epidermal Sheets in Mammalian Tissue Morphogenesis, Evan Heller

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Chromatin Control of the Antiviral Response to Influenza, Jessica Sook Yuin Ho

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Identification of a Functional Hotspot on Ubiquitin Required for Stimulation of Methyltransferase Activity on Chromatin, Matthew Thomas Holt

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High Resolution Maps of the Vasculature of An Entire Organ, Oppenheim N. Jacob

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The Structural and Biochemical Characterization of Salmonella Host Specificity Determinant Gifsy-2 Gene E, Amanda C. Kohler

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Functional and Structural Studies of the Human Voltage-Gated Proton Channel, James Anthony Letts

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The Neuropeptide Regulation of Host-Seeking Behavior in Aedes Aegypti Mosquitoes, Jeff Liesch

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RNA Deregulation in Metastatic Breast Cancer, Christina Beate Marney

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Identification of a Microrna Network that Regulates Melanoma Metastasis and Angiogenesis by Targeting Apoe, Nora Pencheva

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Causes and Consequences of Genetic Robustness and Fragility in HIV-1 Proteins, Suzannah J. Rihn

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The Origin of Multiple Sclerosis Revisited: The Case for a Soluble Toxin, Kareem Rashid Rumah

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HIV Specific B Cell Response in Patients With Broadly Neutralizing Serum Activity, Johannes F. Scheid

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Split Inteins: From Mechanistic Studies to Novel Protein Engineering Technologies, Neel H. Shah

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Exploration of Cell Cycle-Specific Essential Gene Functions in the Microbial Plant Chlamydomonas Reinhardtii, Frej Tulin

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Mechanism and Evolutionary Origins of HIV-1 Virion Entrapment by Tetherin, Siddarth Venkatesh

2013

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Decoding 5HMC as an Active Chromatin Mark in the Brain and its Link to Rett Syndrome, Pinar Ayata

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Cannabinoid CB1R Receptor Mediates Metabolic Syndrome in Models of Circadian and Glucocorticoid Dysregulation, Nicole Bowles

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Discovery and Characterization of Methylation of Arginine 42 on Histone H3: A Novel Histone Modification with Positive Transcriptional Effects, Fabio Casadio

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Telomere-Driven Tetraploidy and its Relevance to Cancer, Teresa Davoli

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Analysis of Small Molecule Inhibitors Aimed at Bacterial Virulence, Paul Daniel Dossa

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Mechanism of Translational Control by the Fragile X Mental Retardation Protein and Creation of the FMRP CTAG Mouse, Sarah Van Driesche

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RNA Dynamics in T Cell Activation, Emily Conn Gantman

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Application of Genetically-Encoded Photoactivatable Crosslinkers to Map Ligand-Binding Sites on G Protein-Coupled Receptors, Amy Grunbeck

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Novel Molecules from Environmental DNA-Derived Type II Polyketide Biosynthetic Gene Clusters, Ryan W. King

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Studies of G Protein-Coupled Receptor Stability and Dimerization Using Novel Fluorescence and Crosslinking Approaches, Adam Knepp

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Examining the Regulation of Cell Division by the Spindle Assembly Checkpoint, Maria Maldonado

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Frequency Selectivity of Synaptic Exocytosis in Hair Cells of the Bullfrog's Amphibian Papilla, Suchit H. Patel

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Deep Brain Stimulation to Increase Generalized Arousal in Intact Mice and a Mouse Model of Traumatic Brain Injury, Amy Wells Quinkert

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Top-Down Control of Lateral Interactions in Visual Cortex, Nirmala Ramalingam

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Phenotypic and Genotypic Models of Streptococcal Colonization of the Human Tonsil, Dennis J. Spencer

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Tuning of Neuronal Excitation by a Brain Specific Microrna MIR-128: From Targets to Behavior, Chan Lek Tan

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An Analysis of Synaptotagmins in Caenorhabditis Elegans, Laura Winzenread

2012

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Exploring Synaptic Vesicle Exocytosis, Pablo Ariel

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Dissecting Synaptic Vesicle Endocytosis, Moritz Armbruster

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Structure and Organization of Nuclear Pore Proteins, Claire Atkinson

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PHDS, Stress, And Starvation: The Identification Of A New RPD3 Deacetylase Complex Involved In The Yeast Oxidative Stress And Metabolism Pathways, Lindsey A. Baker

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Efforts Toward Production of Novel Natural Products From Uncultured Soil Microbes, Jacob Joseph Banik

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Induction of Innate and Adaptive Immunity In Vivo by Selective Antibody Targeting of Poly dA:dT and Antigen to Dendritic Cells, Scott A. Barbuto

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Vocal Handedness: The Emergence of Lateralization at Fledging, Rudy Bellani

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Genetic Variation in Neurotransmitter Receptors Generates Behavioral Diversity, Andres Bendesky

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Chemical Reporters for Investigating Lipidated Proteins at the Host-Pathogen Interface, Guillaume Charron

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The Application of Functional Metagenomics to Natural Products Research, Jeffrey William Craig

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Characterization of the Central Cavity of a Potassium Channel: Helix Dipoles, Conformational Plasticity and Inhibition, Disan Schold Davis

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Dissecting Mammalian Replication-Independent Chromatin Assembly – Biochemical and Structural Studies on the H3.3-Specific Histone Chaperones Hira and Daxx, Simon Elsässer

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Chemical Reporters for Bacterial Pathogenesis and Beyond, Markus Grammel

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The Neural Circuit for Behavioral Responses to Pheromone and Social Behavior in Caenorhabditis Elegans, Heeun Jang

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Analysis of Behavior in Populations of Swimming Microbes, David Jordan

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Identification of a Novel Regulator of ER Stress-Induced Apoptosis, Genevieve S. Joseph

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The Dynamic Streptococcus Pyogenes Transcriptome in the Host Cell Environment and Contributions by Phage, Barbara Juncosa

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WIP1 Phage Specificity for B. Anthracis, Sherry Kan

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The Extent and Nature Of Chromosomal Rearrangements in B Lymphocytes, Isaac Andrew Klein

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Structural and Functional Studies of SLO K+ Channels: Mechanisms of Gating by Intracellular Signaling, Manuel D. Leonetti

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Roles of the Methylcitrate and Methylmalonyl-COA Pathways in Mycobacterial Metabolism and Pathogenesis, Manisha Ulhas Lotlikar

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The GluK4 Kainate Receptor Subunit Regulates Mood, Memory and Excitotoxic Neurodegeneration, Emily Rhodes Lowry

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Conserved and Novel Properties of Clathrin-Mediated Endocytosis in Dictyostelium Discoideum, Laura Macro

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Structure Function Analysis of Adenosine Deaminase Acting on tRNA (ADAT2) from Trypanosoma Brucei, Miller Marshall

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The Expression of the Zinc Finger Transcription Factor zDC Defines the Classical Dendritic Cell Lineage, Matthew M. Meredith

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The Diversity of Cortical Interneurons, Miho Nakajima

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Progress Towards Integrated Models of HCV Dynamics, Thomas S. Oh

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rRNA Promoters as Targets for Transcription Factors: Structural and Functional Studies of PhERI and CarD, Joseph S. Osmundson

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Micrornas in Breast Cancer Metastasis: Molecular Regulation of Endothelial Recruitment by Cancer Cells & Regulation of Metastasis Suppressor Micrornas, Kim J. Png

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Glia Delimit Shape Changes Of Sensory Neuron Receptive Endings in C. elegans, Carl Procko

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Protein Phosphatase 1 at the Kinetochore Regulates Chromosome Segregation, Jessica Scott Rosenberg

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Molecular and Functional Characterization of Pyramidal Cell Types in the Frontal Cortex of Mouse Brain, Prerana Shrestha

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Sample Path Analysis of Integrate-and-Fire Neurons, Thibaud Taillefumier

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Examining Intracellular Phosphorylation Gradients During Cell Division, Lei Tan

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Approaches to Study Small Molecule Inhibitors and Their Targets, Sarah Anne Wacker

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Variability in Singing and in Song in the Zebra Finch, Cameron Wellock

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Using "Designer" Nucleosomes to Study Enzymatic Crosstalk Between Histone Ubiquitylation and Histone Methyltransferases, Sarah J. Whitcomb

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Mechanisms That Ensure the Proper Terminal Structure of Mammalian Telomeres, Peng Wu

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Develoment and Application of Chemical Strategies to Study Protein Fatty-Acylation in Eukaryotes, Mingzi Zhang

2011

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Defining Gene Expression in Normal Human Epidermal Keratinocytes and Melanocytes: A Prerequisite for Understanding Hyperplastic and Neoplastic Pathology, Erika de Wyllie Billick

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The Role of 53BP1 in DNA Double-Strand Break Repair, Anne Helen Bothmer

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DRE-1/FBXO11, A Conserved F Box Protein, Regulates Apoptosis in C. elegans and is Mutated in Human Lymphoma, Michael Chiorazzi

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Assessing the Phylogenetic and Cultural Content of Learned Song, Nicole Creanza

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From Microarrays to Behavior: Genes Controlled by Feeding State in Mosquitoes and Flies, Shelli F. Farhadian

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Cell-Type Specific Translational Profiling in Huntington's Disease Mouse Models, Robert J. Fenster

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Long-Term Quantitative Microscopy: From Microbial Population Dynamics to Growth of Plant Roots, Zak Frentz

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Antigen presentation : Influence of Cell Type and Route of Antigen Uptake, Alice O. Kamphorst

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Spatial Control of CDC42 Activation Regulates Cell Width and Growth Zone Formation, Felice D. Kelly

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Natural Product Biosynthesis In Uncultured Bacteria, Jeffrey Kim

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The Role of the Stereociliary Glycocalyx in Hair Bundle Cohesion, Adria Claire Le Boeuf

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Rapid Functional Dissection of Genetic Networks Via RNAi In Mouse Embryos, Geulah Livshits

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Regulation of Polarized Protein Transport to Axons, Dendrites, and Sensory Cilia in Caeborhabditis Elegans Neurons, Tapan Apurva Maniar

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Studies of the Kinetics of Cell Cycle Processes in S. Cerevisiae: The Molecular Basis of Start Irreversibility and Cyclin-Cdk Ordering of Mitotic Events, Catherine Oikonomou

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Sensory Organ Morphogenesis in Caenorhabditis Elegans, Grigorios Oikonomou