Student Theses and Dissertations

 

The Rockefeller University has awarded over one thousand Ph.D’s since 1959. This collection contains theses beginning with the graduating class of 2006. Earlier theses are added by request or as permission to digitize is received. For more information visit the FAQ page.

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2021

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Restriction of Food Intake by Dorsomedial Hypothalamus, Caner Caglar

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Cerebral Amyloid Angiopathy-Causing Beta-Amyloid Variants Have Altered Effects on the Clotting System, Steven Cajamarca

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Mechanisms for the Evolution of Superorganismality in Ants, Vikram Chandra

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Non-Canonical Axonal Insulin Receptor signaling Drives Aversive Olfactory Learning, Du Cheng

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Unraveling the Interaction Between Beige Adipocytes and the Sympathetic Nervous System, Jingyi Chi

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Linker Histone Medicated Regulation of Mitotic Chromosome Compaction and Individualization, Pavan Choppakatla

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Brochemical Studies of Peptidoglycan Hydrolases from Commensal and Pathogenic Bacteria, Juliel Espinosa

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Finding Common Ground: The Common Marmoset as a Model to Accessing and Providing Insight into the Social Brain, Margaret Fabiszak

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Tension Propagation Along Tip-Link Cadherins: Regulation and Implications for the Auditory System, Daniel M. Firester

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Deciphering Cancer Metabolic Dependencies in the Tumor Microenvironment, Xiphias Ge Zhu

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The Role of DNA Methylation in Defining the Vocal Learning Transcriptome of the Zebra Finch, Caitlin Sun Gilbert

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The Role of Nutrient Availability in Therapeutic Response of Leukemia, Rohiverth Guarecuco Jr

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Not Black and White: BMP Signaling Drives Melanocyte Differentiation Down Stream of Stem Cell Activation, Nicole Rai Infarinato

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The Taste of Blood, Veronica Jove

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Single-Molecule Investigation of Chromatin-Associated Factors in Genome Organization and Epigenetic Maintenance, Rachel Leicher

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Pathogenic Characterization and Therapeutic Development for Fiblrolamellar Hepatocellular Carcinoma, Solomon N. Levin

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Structural Study of Disease Relevant ABC Transporters-Cystic Fibrosis Transmembrane Conductance Regulator and ABCA4, Fangyu Liu

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A Role for ACSBG1 in Obesity-Accelerated Breast, Olivia Maguire

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Interactions Between Microbial, Neuronal, and Immune Cells in the Digestive System, Fanny Matheis

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Genome-Wide Human-Specific RNA Regulatory Elements in the Brain, Elisabeth A. Murphy

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Characterizing Inflammatory Mechanisms in Hidradenitis Suppurativa, Kristina Navrazhina

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Noggin Transport in a Model Human Epiblast, Tiên Phan-Everson

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Accessory Nucleases Provide Robust Antiparasite Immunity for Type III CRISPR-Cas Systems, Jakob Træland Rostøl

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A Proteomic Approach to Elucidating the Function of Picornavirus 2A Protease, Artem Serganov

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A Translational Approach to Modeling Unique Aspects of Germ Cell Development During Self-Organization of the Primate Embryo, Rohan R. Soman

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Developmental Dynamics of 5-Hydroxymethylcytosine and its Role in the Terminal Differentiation of Neurons, Elitsa Stoyanova

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A-to-I RNA Editing in Human Cells, Tony Sun

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Chemical Tools for Exploring Metabolite Interactions with Nuclear Receptors and Beyond, Taku Tsukidate

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The Identification of a Leptin Dependent Neural Pathway Regulating Adipose Tissue Innervation, Putianqi Wang

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Quantifying the Release of Protein Substrates from AAA+ ATPase ClpX by Single Molecule Total Internal Reflection Fluorescence Microscopy, Xiao Wang

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The Role of Compartmentalized Metabolism in Cellular Metal Homeostasis, Ross A. Weber

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Transcriptional Regulation of the Metabolic Response to Therapy in Leukemia, Robert Thomas Williams

2020

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The Role of Adipocytes in the Tumor Microenvironment in Obesity-Driven Breast Cancer Progression, Sarah Ackerman

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Blood-Derived Plasminogen Modulates the Neuroimmune Response in Both Alzheimer's Disease and Systemic Infection Models, Sarah K. Baker

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Characterizing the RNA Editing Specificityof ADAR Isoforms and Deaminase Domains In Vitro, Mariel Therese Bartley

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Visualizing Protease Activation, Retrochmp3 Activity, and VPR Recruitment During HIV-1 Assembly, Kate Bredbenner

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Hybridization in Ants, Ian Butler

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Time-Restricted Feeding Extends Longevity in Drosophila Melanogaster, Daniel Cabrera

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Structural and Functional Studies of the Unconventional Proteobacterial Transcription Activator CRL in Complex with the Transcription Machinery, Alexis Jaramillo Cartagena

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Cryo-EM Studies of Bacterial RNA Polymerase, James Chen

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DDI1/2 and RTF2-Dependent Regulation of RNASE H2 at the Replisome Ensures Genome Stability, Brooke A. Conti

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Diverse Kappa Opioid Receptor Agonists: Relationships Between Signaling and Behavior, Amelia Dunn

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Monogenic Defects of the Type 1 Interferon Signaling Pathway in Human: Molecular and Clinical Implications, Nicholas Hernandez

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Monogenic Defects of the Type I Interferons Signaling Pathway in Humans: Molecular and Clinical Implications, Nicholas Hernandez

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Small Molecule Activation of Yap for Inner-Ear Regeneration and Beyond, Nathaniel Kastan

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Small-Molecule Activation of YAP for Inner-Ear Regeneration and Beyond, Nathaniel Kastan

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Molecular Mechanisms and Antigen Receptor Requirements for Lymphocyte Adaptation to Intestinal Tissues, Mariya B. London

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Identification of Previously Unknown Interactions Between G Protein-Coupled Receptors and Receptor Activity-Modifying Proteins, Emily Margaretha Lorenzen

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Sympathy for the Microbiota: How Changes in Gut Microbial Composition Influence the Immune System and Basic Physiology by Way of the Sympathetic Nervous System, Paul Andrew Muller

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Mechanisms of Evasion: Anti-Tumor Immune Suppression & TRNA-Dependent Growth in Cancer Metastasis, Lisa Brooke Noble

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Cas9-Primed Adaptive Immunity During the CRISPR-Cas Response, Philip M. Nussenzweig

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A Network Approach to Understanding miRNA Regulation in Adipose Tissue, Sean O’Connor

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Germline Genetic Determination of Cancer Outcome, Benjamin N. Ostendorf

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Dissection of Neurons and Circuits Involved in Regulating Innate Behaviors, Movement and Higher Cognitive Functions in Mice, Luca Parolari

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Analyzing Resistance to Design Chemical Inhibitors of AAA Proteins, Rudolf Pisa

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Chemical Biology of Dynein, Cristina C. Santarossa

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A Role for Mindbomb 1 in Adenovirus Genome Delivery, Stephanie Sarbanes

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Genetic Functional Dissection of the Synaptic Output of a Dual-Function Integrating Neuron, Aylesse Sordillo

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Testing the T-loop Model of Telomeric End Protection, Leonid Alexeevich Timashev

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CRISPR/CASTE: Functional Genomic Studies of the Major Evolutionary Innovations of Ants, Waring Trible

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Identification of Gene Expression Changes in Sleep Mutants Associated With Reduced Longevity in Drosophila, Zikun Wang

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Molecular Characterization of Mammalian De Novo DNA Methyltransferase Chromatin Recruitment, Daniel N. Weinberg

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Cell Memory and Fate in Human Development, Anna Kresovich Yoney

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Representations of Reward and Movement in Drosophila Dopaminergic Neurons, Aryeh Zolin

2019

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In Vitro, In Vivo, and In Silico Studies of Reticulospinal Circuits and Generalized Arousal, Adele Bubnys

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Chemical Biology, Biochemical and Structural Studies of MDN1, an AAA Protein Required for Ribosome Biogenesis, Zhen Chen

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Sensory Coding and Olfactory Integration in Caenorhabditis Elegans, May Dobosiewicz

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On the Interactions of Augmin with Microtubules and the Mechanics of the Cross-Linker PRC1, Alejandro Dottore

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Spontaneity and Precision in the Drosophila Central Nervous System, Bennett Ferris

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Regulation of Protein Degradation by ADP-Ribosylation, Yetis Gultekin

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Dopamine and the Temporal Dependence of Learning and Memory, Annie Handler

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Generation of Memory of Infection During the CRISPR-Cas9 Immune Response, Robert Heler

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A Stress-Induced TRNA Depletion Response Mediates Codon-Based Translational Repression and Growth Suppression, Doowon Huh

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Elucidation of the Functional Architecture of the Early Pre-Ribosomal Processing Machinery in Yeast, Mirjam Hunziker

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Substrate Identification of an Oncogenic Kinase: Elucidating the Pathogenesis of a Rare Liver Cancer, Melissa Jarmel

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Modeling Alzheimer's Disease Using CRISPR/CAS9 Gene Editing and Induced Pluripotent Stem Cells Reveals Conserved Cellular Mechanisms, Dylan Kwart

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From Face Perception to Individual Recognition: The Missing Link, Sofia Mariana Landi

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The Skin Remembers: Epigenetic Memories of Inflammation Past, Samantha B. Larsen

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Molecular Mechanisms Underlying Stress-Induced GLIA Remodeling in the Nematode C. Elegans, In Hae Lee

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Multimodal Strategies of Host-Seeking Mosquitoes, Molly Zhen Liu

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Oxytocin, Dopamine, and the Neuromodulation of Mating Behavior in C. Elegans, Meghan Aileen Lockard

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Neural Mechanisms that Control an Innate Foraging Behavior in Caenorhabditis Elegans, Alejandro Lopez-Cruz

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The Role and Control of WNT Signalling in an HESC Model of Human Primitive Streak, Iain Martyn

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Functional Organization of Molecular Memories in the CRISPR-Cas Immune System, Jon McGinn

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Center Manifold Dynamics in Randomly Coupled Oscillators and in Cochlea, Dimitrios Moirogiannis

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Distinct Populations of Layer 5B Pyramidal Neurons in the Primary Motor Cortex, Maria V. Moya

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Examining Mechanisms Regulating Microtubule Assembly and Function, Melissa Pamula

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Conformational Dynamics of the Nuclear Pore Complex Studied With Coarse-Grained Modelling and Polarized Light Microscopy, Joan Pulupa

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Molecular Characterization of Novel Mutations in Fanconi Anemia Patients, Kimberly Rickman

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The Role of ZMYND8 in Immunoglobulin Class Switch Recombination, Daniel Benjamin Rosen

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Non-Coding RNA Features Critical to the Replication of HIV-1, Matthew A. Takata

GPCR Activation of the G Protein-Gated Inward Rectifier Potassium Channel, Kouki Touhara

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GPCR Activation of the G Protein-Gated Inward-Rectifier Potassium Channel, Kouki Touhara

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Who Said That? Towards a Machine-Prediction-Based Approach to Tursiops Truncatus Whistle Localization and Attribution in a Reverberant Dolphinarium, Sean Fisher Woodward

2018

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Cell Cycle Control by Cyclin-CDKS in Chlamydomonas ReinhardtII, Kenneth C. Atkins

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Making Ribosomes: Biochemical and Structural Studies of Early Ribosome Biogenesis in Yeast, Malik Chaker-Margot

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Single Cell Analysis of the HIV-1 Latent Reservoir, Lillian Brumer Cohn

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Dopaminergic Modulation Shapes Sensorimotor Processing in the Drosophila Mushroom Body, Raphael Cohn

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Multi-Modal Effects of the Repellent Deet Across Protostomia, Emily Jane Dennis

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Biological Consequences of Atypical Phage Conversion in Gram-Positive Pathogens, Douglas R. Deutsch