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Pfaff, D. Drive
The Rockefeller University
Donald W. Pfaff. Drive: neurobiological and molecular mechanisms of sexual motivation
What arouses an animal or human from an inactive, nonresponsive state to a condition of activity and responsiveness? What are the biological mechanisms for this change? In this book, Donald W. Pfaff focuses on a reproductive behavior typical of many female animals. Sensory stimuli from the male trigger responses in a well-defined circuit of nerve cells. At the top of the circuit, certain nerve cells receive and retain sex hormones such as estrogens and progesterone. As a result, specific genes in these nerve cells are turned on at specific times, affecting, in turn, the rest of the neural circuit and causing a state of sexual responsiveness.
According to Pfaff, the biological bases for the most primitive human drives are largely explained by mechanisms uncovered in animal brains that have not changed in their fundamental properties over millions of years of evolution. Focusing on a single instinctive behavior, in this case, the sex drive is an important step toward understanding the biological reasons for the change from unmotivated to motivated animal behavior.
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Pfaff, D. /Editor Hormones, brain and behavior
The Rockefeller University
Donald W. Pfaff, Arthur Arnold, Anne M. Etgen, Susan E. Fahrbach, Robert T. Rubin/editors. Hormones, brain and behavior
2nd edition
Hormones, Brain and Behavior is a comprehensive work discussing the effect of hormones on the brain and, subsequently, behavior. This major reference work of more than 100 chapters covering a broad range of topics with an extensive discussion of the effects of hormones on insects, fish, amphibians, birds, rodents, and humans. To truly understand all aspects of our behavior, we must take every influence (including the hormonal influences) into consideration. Donald Pfaff and a number of well-qualified editors examine and discuss how we are influenced by hormonal factors, offering insight, and information on the lives of a variety of species.
Hormones, Brain and Behavior offers the reader broad coverage of the growing field of research, with a state-of-the-art overview on hormonally-mediated behaviors. This reference provides unique treatment of all major vertebrate and invertebrate model systems with excellent opportunities for relating behavior to molecular genetics. The topic covers an unusual breadth (from molecules to ecophysiology), ranging from basic science to clinical research, making this reference of interest to a broad range of scientists in a variety of fields.
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Pfaff, D. Estrogens and brain function
The Rockefeller University
Donald W. Pfaff. Estrogens and brain function: neural analysis of a hormone-controlled mammalian reproductive behavior
By integrating a vast array of empirical findings, this book advances the frontier of knowledge about estrogen’s effects on nerve cells and behavior. Systematically examining the effects of estrogen on the neural circuitry underlying reproductive behavior, the author uses electrophysiological, neuroanatomical, and neuroendocrine experimental techniques to develop a complete analysis of the mechanisms for essential mammalian mating behavior.
Based on an extensive research program, Estrogens and Brain Function traces the pathways that control lordosis behavior. This book also describes the anatomical basis of hormonal accumulations in the brain and illustrates how these hormones alter neural circuits. Both the methods and the results delineated here promise to have an important impact on future investigations of brain mechanisms of mental and behavioral states.
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Pfaff, D. Genetic influences on neural and behavioral functions
The Rockefeller University
Donald W. Pfaff. Genetic influences on neural and behavioral functions
The concept underlying this book is the contributions of new genomic information to review some of understanding neural and behavioral functions. In some cases, these are already recognized as having strong hereditary components, while in others, the contributions of specific gene products may soon be discovered. Utilizing the flood of new information derived from the Human Genome Project and corresponding efforts to elucidate the mouse genome." Genetic Influences on Neural and Behavioral Functions" provides a scholarly catalog, organized logically, of relations between the expression of specific genes, nerve cell biology and behavior, normal and abnormal, in animals AND humans. Sample topics include genes in relation to schizophrenia, panic disorder, epilepsy, alcoholism, sleep, eating disorders, and more.
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Pfaff, D. Origins of Human Socialization
The Rockefeller University
Donald W. Pfaff. Origins of human socialization
Origins of Human Socialization introduces a new concept on the origins of basic human instinct. The book combines the three disciplinary approaches, including neuroscience, paleoanthropology, and developmental psychology as an intertwined foundation for prosocial behavior. It argues that humans have the basic brain mechanisms for prosocial activity, offering new insights into more sophisticated social behavior. It also examines both visual and auditory systems in both humans and animals to explain the evolution of social interactions. Written by world-renowned researcher Dr. Donald Pfaff, this book is the first to explore why we have basic social instinct and how it works.
For centuries, researchers have argued over the foundations of human behavior in society. Anthropologists point to transitions from hunter/gathers to urban dwellers leading to human domestication. Developmental psychologists highlight social competencies in babies. Neuroscientists focus on specific genetic and neurochemical mechanisms that attribute to social behavior. This book brings all of these important areas together in an interdisciplinary approach that helps readers understand how they are linked.
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Pfaff, D. Principles of homone/behavior relations
The Rockefeller University
Pfaff, Donald W., Phillips, M. Ian., Rubin, Robert T. Principles of Hormone/Behavior Relations
This text introduces underlying principles of the endocrine regulation of behavior in animals and humans. Every chapter begins by stating a principle, followed by specific examples of hormone actions derived from scientific experiments and clinical observations, and concludes with a few challenging unanswered questions. The reference source Hormones, Brain & Behavior identified this field as rapidly expanding within neurobiology and endocrinology. Now, this well-illustrated and referenced text will serve students from undergraduate school to medical school as they learn this new discipline.
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Pfaff, D. The neuroscience of fair play
The Rockefeller University
Donald W. Pfaff. The neuroscience of fair play: why we (usually) follow the Golden rule
Pfaff, the researcher who first discovered the connections between specific brain circuits and certain behaviors, contends that the basic ethics governing our everyday lives can be traced directly to brain circuitry. Writing with popular science journalist Sandra J. Ackerman, he explains in this clear and concise account how specific brain signals induce us to consider our actions as if they were directed at ourselves—and subsequently lead us to treat others as we wish to be treated. Brain hormones are a part of this complicated process, and The Neuroscience of Fair Play discusses how brain hormones can catalyze behaviors with moral implications in such areas as self-sacrifice, parental love, friendship, and violent aggression. Drawing on his own research and other recent studies in brain science, Pfaff offers a thought-provoking hypothesis for why certain ethical codes and ideas have remained constant across human societies and cultures throughout the world and over the centuries of history. An unprecedented and provocative investigation, The Neuroscience of Fair Play offers a new perspective on the increasingly important intersection of neuroscience and ethics. ~ Google Books
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Ratliff, F. / Editor Studies on excitation and inhibition in the retina
The Rockefeller University
Floyd Ratliff, H. Keffer Hartline. Studies on excitation and inhibition in the retina: a collection of papers from the laboratories of H. Keffer Hartline
For nearly half a century, H. Keffer Hartline has conducted research on vision and the retina. His research has extended into many and diverse branches of the field, and he has studied the retinas of various representatives of each of the three major phyla having well-developed eyes – the arthropods, the vertebrates, and the mollusks. These comparative studies have elucidated numerous fundamental principles of retinal physiology which, over the years, have provided the foundation for many advances in the neurophysiology of vision. This collection of papers from his laboratory begins with one published early in his career when and Clarence H. Graham first recorded the electrical activity of single optic nerve fibers and thereby initiated the quantitative unitary analysis of the roles played by excitation and inhibition in the integrative action of the retina.
Ending with his recently published Nobel Lecture on the unitary analysis of retinal mechanisms of vision, the collection thus spans the entire history of this major branch of visual physiology.
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Reeke, G./Editor Modeling in the neuroscience
The Rockefeller University
George N. Reeke. Modeling in the Neurosciences: from biological systems to neuromimetic robotics
Physiologically realistic and integrative models of the brain are the only way forward to lift us clear of the jungle of detail about the brain. The essence of brain function dynamics that they embody will serve as the fundamental fulcrum around which new details (parameters) can be added and tested across the scale. This book exemplifies a realistic way forward for an explicit 'integrative neuroscience'.
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Rice, C. /Editor The hepatitis C viruses
The Rockefeller University
Charles M. Rice, Curt H. Hagedorn/editors. The hepatitis C viruses
Series: Current topics in microbiology and immunology ; v. 242
Chronic hepatitis C is a major worldwide health problem affecting more than 170 million people. Chronic infections lead to cirrhosis and liver failure or hepatocellular cancer in many instances. This volume includes comprehensive reviews that cover much of the vast literature that has appeared since the identification of the hepatitis C virus RNA genome. It will be an invaluable collection for anyone wanting an up-to-date picture of HCV transmission, molecular virology, immune response, cellular/molecular pathogenesis, and possible avenues for developing effective new therapeutics and vaccines.
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Rivers, T./Editor Viral and rickettsial infections of man
The Rockefeller University
Thomas M. Rivers, Frank Lappin Horsfall. Viral and rickettsial infections of man
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Rivers, T. Tom Rivers: reflections on a life in medicine and science
The Rockefeller University
Thomas M. River, Saul Benison. Tom Rivers: reflections on a life in medicine and science; an oral history memoir
In the last few months of his life, an eminent pioneer in the field of virology looks back over his eventful career and through the medium of oral history leaves behind him an authoritative account of the genesis of this important branch of science. The book is a record, edited only for reading convenience, of a series of tape-recorded interviews of the late Dr. Thomas M. Rivers of the Rockefeller Institute for Medical Research. The interviewer, Saul Benison, is a historian of medicine and science who equipped himself for the task through extensive research in hitherto unused primary source materials. What emerges is an autobiography presented in Dr. Rivers' conversational style, reflecting his colorful personality, and spanning a long and eventful period of biomedical investigation.
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Robinson, C. Adventures in medical education; a personal narrative of the great advance of American medicine
The Rockefeller University
George Canby Robinson. Adventures in medical education; a personal narrative of the great advance of American medicine
The author introduces his subject with a brief history of medical education up to the beginning of the present century. The autobiographical account begins when the author entered the Johns Hopkins Medical School and continues with his training in the Pennsylvania Hospital and in the Medical Clinic of Friedrich Müller in Munich. Subsequently, Dr. Robinson took part in organization and administration as well as in teaching and research in the Rockefeller Institute for Medical Research, and in several university medical schools; he gives an account of the development of these institutions and of the men who took prominent parts in the new era of scientific medicine in this country.
Adventures in Medical Education describes how medical research evolved and how modern medicine spread to such key institutions as Washington University in St. Louis and Vanderbilt University in Nashville, how it grew in China at the Peiping Union Medical College, and finally how it was used in New York City at the Cornell Medical School.
Concluding with a discussion of some basic principles and present-day problems of medical education, the author shows how important medical developments constitute an integral part of our cultural history.
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Sabin, F. An atlas of the medulla and midbrain
The Rockefeller University
Florence Rena Sabin. An atlas of the medulla and midbrain: a laboratory manual
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Sabin, F. Franklin Paine Mall, the story of a mind
The Rockefeller University
Florence Rena Sabin. Franklin Paine Mall, the story of a mind
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Schoenfeld, R. Exploring the nervous system
The Rockefeller University
Robert L. Schoenfeld. Exploring the nervous system: with electronic tools, an institutional base, a network of scientists
A study of outstanding research in neuroscience and of the researchers during the 20th century with emphasis on the English, Americans, particularly the Rockefeller University students and professors.
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Seitz, F. Electronic genie : the tangled history of silicon
The Rockefeller University
Frederick Seitz, Norman G. Einspruch. Electronic genie: the tangled history of silicon
From that opening pronouncement, Electronic Genie takes its readers on a two-century journey that began with Antoine Lavoisier's prediction of the existence of silicon as an element. It traces the emergence of silicon as key to the development of most forms of today's electronics and its role in making possible the revolutionary digital computer. Loaded with information about such original thinkers as Lavoisier, John Bardeen, Bill Gates, Patrick Haggerty, Gordon Moore, and many more, the volume traces the use of silicon in metallurgy, as a diode rectifier in wireless and radio, and ultimately as a nonlinear element for heterodyne mixing in radar during World War II. Written by two well-known figures in the field, Electronic Genie will appeal to students of science and technology as well as to anyone interested in the history of these fields.
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Seitz, F. On the frontier : my life in science
The Rockefeller University
Frederick Seitz. On the frontier: my life in science
On the Frontier is Frederick Seitz’s long-awaited memoir. Here in brisk, anecdotal style enhanced by dozens of never before published photographs, Dr. Seitz recalls the beginnings of his fascination with scientific inquiry; his academic endeavors at Stanford, Princeton, and the California Institute of Technology; his professional tenures at the Carnegie Institute of Technology, the Defense Department, NATO, and The Rockefeller University; his presidency of the National Academy of Sciences; and more.
But On the Frontier is more than a story of one man. In describing his life and times, his friends and colleagues, and the environment in which his career flourished, Frederick Seitz offers an insider’s look at the crucial developments, issues, personalities, and institutions of modern physics over nearly a century of development.
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Seitz, F. The modern theory of solids
The Rockefeller University
Frederick Seitz. The modern theory of solids
Widely considered a classic, the book includes coverage of such topics as the classical theory of ionic crystals, the specific heats of simple solids, the free-electron theory of metals and semiconductors, quantum mechanical foundation, approximate treatment of the many-body problem, molecular binding, the band approximation, approximation methods, cohesive energy, the work function and the surface barrier, excited electron states of solids, electronic structure of the five solid types, dynamics of nuclear motion and the theory of conductivity.
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Shedlovsky, T. Electrochemistry in biology and medicine
The Rockefeller University
Theodore Shedlovsky. Electrochemistry in biology and medicine
Sponsored by the Electrochemical Society, inc., New York
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Spector, L. Covalent catalysis by enzymes
The Rockefeller University
Leonard B. Spector. Covalent catalysis by enzymes
As long as enzymes continue to catalyze, the analytical chemist will use them as components of a sensitive, highly selective, analytically useful reaction. For him, the details of the mechanistic aspects of enzyme catalysis are usually of secondary importance to the occurrence of the catalyzed reaction. Yet the advance of science, including analytical chemistry, ultimately depends on an understanding of all aspects of a subject, and this book provides an unconventional look at the mechanisms of enzyme catalysis. Its thesis is that enzymes, like many other catalysts, function by removing a molecular fragment from a substrate (reactant) to form a compound between that fragment and the enzyme. That fragment is subsequently transferred to a second reactant.
This contrasts with the popular view that the enzyme merely provides a favorable configuration and environment for direct transfer of the fragment between reactants. This “covalent” mechanism is supported by information concerning 465 enzymes, which contrast with a complete lack of information in favor of the “popular” interpretation. To the non-biochemist, at least, the arguments seem very persuasive and do not need the extra lessons in logic, which the author throws in for good measure. The book itself is well prepared and produced, with an abundance of formulas and references, and with a combined author and subject index.
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Stanley, W. Viruses and the nature of life
The Rockefeller University
Wendell M. Stanley. Viruses and the nature of life
Series: New naturalist library [1st ed.]
A number of eminent virologists of the University of California have written this book “for young people and the adult layman.” Dr. Stanley and his guest authors cover such topics as the chemical structure of viruses, how viruses reproduce and how they may cause disease or, in cases, tumors. The latter part of the book describes the chemistry of the nucleic acids essential to life, and the present frontiers of research into the mechanisms of nucleic acid control of virus protein formation. The authors deal also with the apparent paradox of organisms such as the plant virus causing tobacco mosaic disease which, though possessing the capacities for reproduction and mutation characteristics for reproduction and mutation characteristic of living thins, may nevertheless be purified chemically and stored as apparently inert crystals.
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Theiler, M. The arthropod-borne viruses of vertebrates
The Rockefeller University
Max Theiler, Wilbur G. Downs. The arthropod-borne viruses of vertebrates: an account of the Rockefeller Foundation Virus Program, 1951-1970
This volume marks a second major milestone in more than 50 years of productive research by staff members of the Rockefeller Foundation in the field of virology. The first milestone, in 1951, was the publication of STROBE'S Yellow Fever, a detailed account of the isolation of the virus, the development of laboratory procedures for handling it, culminating in the development of a safe and highly effective live, attenuated vaccine, the 17D vaccine, a product still unsurpassed among all virus vaccines for use in man. At first, it seemed as if control of yellow fever could be achieved simply by vaccinating those at risk, but field experience showed that yellow fever virus circulated invertebrate hosts other than man, and this discovery revealed an open-ended problem of enormous complexity. It is now known that the yellow fever virus is merely one among some 300 different viruses that share the property of infecting both vertebrate and invertebrate hosts and which are transmitted to vertebrates by blood-sucking insects in the tissues of which they multiply. The arthropod-borne viruses of vertebrates is a monumental study of this problem by two masters, Max Theiler, who received a Nobel Prize in 1951 for his work on 17D vaccine, and who died shortly before the book was published, and W. G. DOWNS, a former Associate Director of the Rockefeller Foundation and former head of the Yale Arbovirus Laboratory.
The book is divided into three parts. In part I, methods used in handling arboviruses are dealt with, and the interpretation of the results of serological tests is discussed. The mouse protection test, which formed the basis of much early work, is cumbersome and can give different results depending upon several variables. The haemagglutination-inhibition (HAI) test is simpler to perform, but the interpretation of the results of HAI tests is not always easy. The cross-reactions demonstrated by HAI tests lead to the concept of antigen " groups ", which form the basis by which arboviruses are classified, and this field is well covered in Part II of the book. There is a useful historical account of the evolution of arbovirus groups, with separate chapters for each of the major groups. These include a chapter on the Tacaribe group viruses, although present views classify these as arenaviruses and exclude them from the arthropod-borne viruses.
Part III is headed "Certain specific problems ", and covers geographical distribution, the arthropod hosts and the vertebrate hosts, with the special case of a man considered in relation to the 101 distinct arthropod-borne viruses which can cause infections in man. The book ends with an alphabetically arranged list of named arboviruses, giving cross-references to the Catalogue of Arthropod-borne Viruses of the World (1967) and its 1970 Supplement, and indicating the relevant group of each virus. This Appendix alone would make the book a valuable key to the complexities of the arboviruses. No less than 92 tables are included within the text, covering such points as the zoogeographic distribution of arthropod-borne viruses, viruses isolated from Rodentia, from ticks, from Chiroptera, and many other facts never previously assembled together. Although the balance of the material is heavily weighted towards the arboviruses of the Nearctic and Neotropical regions, sufficient mention is made of arboviruses from other regions to justify the title. The book is likely to prove indispensable to any laboratory dealing with these viruses. --J. S. Porterfield
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Trager, W. Living together: the biology of animal parasitism
The Rockefeller University
William Trager. Living together: the biology of animal parasitism
For more than 50 years, Professor William Trager has bent his efforts toward understanding parasites: how they get from one host to another, how they recognize and enter appropriate hosts and find their way to particular organs and cells, how they are sheltered or rejected. He has studied their nutritional requirements and their genetics. A decade ago, he achieved the successful test tube cultivation of a malaria parasite.
In a new book, Living Together: The Biology of Animal Parasitism, he tells the story of what he and others have learned about the creatures who live on other creatures, and of the efforts to control parasitic diseases, “not only to present what is known,” he writes, “but also to reveal the great gaps in our knowledge and the fascinating work yet to be done.”
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