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Kaiser, E. /Editor Synthetic peptides: approaches to biological problems
The Rockefeller University
James P. Tam, Emil Thomas Kaiser/editors. Synthetic peptides: approaches to biological problems: proceedings of a Glaxo-UCLA colloquium held at Park City, Utah, January 31-February 4, 1988
Series: UCLA symposia on molecular and cellular biology; new ser., v. 86
Synthetic peptides: approaches to biological problems comprehensively reviews the importance of peptides and synthetic chemistry in solving biological challenges, with special attention given to the use of peptides in the development of synthetic vaccines. The book examines in detail how synthetic peptides can be used to define the structure and function of various biological interactions (e.g., hormone-receptor, antigen-antibody, substrate-enzyme, and protein-DNA), and discusses how a better understanding of the syntheses, structures, and applications of the peptides themselves is leading to new approaches for their use in addressing a variety of biological problems.
Divided into six sections, this authoritative volume provides new insights into such pertinent topics as methods of peptide application, prediction of peptide and protein structure, synthetic peptide-based vaccines, determination of antigenic domains, bioactive conformations of peptide hormones, and peptide hormones and growth factors. In addition, the compilation focuses on research related to the application of synthetic peptides in the field of immunology. Other topics covered include polar interactions in proteins, mapping of immunodominant epitopes, the next generation of foot-and-mouth-disease vaccines, and the use of synthetic peptides for the analysis of hepatitis B virus.
The book will be of interest to biochemists, immunologists, oncologists, virologists, toxicologists, pathobiologists, and pharmacologists.
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Kaiser, E. Radical ions
The Rockefeller University
Emil Thomas Kaiser, Larry Kevan. Radical ions
Series: Reactive intermediates in organic chemistry
This is a collection of 13 papers that deal with the recent developments in the chemistry of radical ions. The first eight chapters cover the theoretical and experimental aspects of organic radicals in solution. Although there is no apparent attempt to present these chapters from a systematic point of view, the topics chosen do seem to give a fairly good, up-to-date, and overall perspective of the radicals. Since electron paramagnetic resonance (EPR) is uniquely suited for investigation of these systems, most of the discussions are based on the interpretation of the EPR spectra. Recent important developments such as theoretical calculation of spin densities, electronic structure of anion and cation radicals, ion-ion-pair equilibria, and molecular conformation studies are treated in considerable detail. The other five chapters are devoted to the chemistry of inorganic radical ions as well as ions produced in rigid media by high energy irradiation. Here again the reader will find that EPR is the dominant experimental tool, although optical methods are also discussed.
The chapters are highly specialized and tend to reflect the interests of the authors, and a sound knowledge of EPR is essential for understanding most of the discussions.
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Krause, R./Editor Antibodies in human diagnosis and therapy
The Rockefeller University
Edgar Haber, Richard M. Kraus/editors. Antibodies in human diagnosis and therapy
The purpose of this volume is to provide a summary of the current state of knowledge of the structure of the antigen combining site, approaches to the synthesis of antibodies by chemical and biological means, and their application in human therapy. The covalent structure of the antibody combining site is analyzed in relation to the specificity of the antigen which it binds. The available three-dimensional models of combining sites are presented showing detailed mechanisms of antigen binding at an atomic level. The concept of the chemical synthesis of antibodies is critically addressed and evaluated as a potential future method for the manufacture of antibodies for therapeutic and diagnostic use.
The authors of this volume include fundamental investigators in the field of immunoglobulin structure, X-ray crystallographers, peptide synthetic chemists, cellular immunologists, and clinical investigators. They combine their diverse interests to give the reader a fascinating glimpse into an exciting and rapidly developing field.
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Krause, R./Editor. Emerging Infections
The Rockefeller University
Richard M. Krause/ editor. Emerging infections
Series: Biomedical research reports
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Kronauer, D. Army Ants: Nature’s Ultimate Social Hunters
The Rockefeller University
Daniel Kronauer. Army Ants: Nature’s Ultimate Social Hunters
A swarm raid is one of nature’s great spectacles. In tropical rainforests around the world, army ants march in groups by the thousands to overwhelm large solitary invertebrates, along with nests of termites, wasps, and other ants. They kill and dismember their prey and carry it back to their nest, where their hungry brood devours it. They are the ultimate social hunters, demonstrating the most fascinating collective behavior. In Army Ants, we see how these insects play a crucial role in promoting and sustaining the biodiversity of tropical ecosystems. The ants help keep prey communities in check while also providing nutrition for other animals. Many species depend on army ants for survival, including a multitude of social parasites, swarm-following birds, and flies. And while their hunting behavior, and the rules that govern it, are clearly impressive, army ants display collective behavior in other ways that are no less dazzling. They build living nests, called bivouacs, using their bodies to protect the queen and larvae. The ants can even construct bridges over open space or obstacles by linking to one another using their feet. These incredible feats happen without central coordination. They are the result of local interactions―self-organization that benefits the society at large. Through observations, stories, and stunning images, Daniel Kronauer brings these fascinating creatures to life. Army ants may be small, but their collective intelligence and impact on their environment are anything but.
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Landsteiner, K. The specificity of serological reactions
The Rockefeller University
Karl Landsteiner. The specificity of serological reactions
Rev. ed. With a chapter on molecular structure and intermolecular forces, by Linus Pauling, and with a bibliography of Dr. Landsteiner's works and a new preface by Merrill W. Chase.
One hundred years after his discovery of the AB0 blood groups, the monumental work of Austrian physician Karl Landsteiner (1868-1943, Nobel Prize 1930) on the specificity of serological reactions is widely recognized. His work on isoantigen reactions included the discovery, together with Levine and Wiener, of the Rhesus factor. Landsteiner did much to develop our understanding of autoantibody reactions and also contributed insights into the etiology of infectious diseases that were rampant in his time. His work in immunochemistry included the discovery of hapten antigenicity. However, most of all he wanted to be remembered for his theory on the specificity of serological reactions, which he had strongly substantiated with his own work. Landsteiner suffered from the shortages in Vienna at the end of World War I. He and his family moved to the Netherlands in 1919. There he worked as a pathologist at the Red Cross Hospital in The Hague until his move to the Rockefeller Institute in New York in 1923. Nowadays, his work is celebrated for its numerous excellent contributions to the fields of transfusion and transplantation medicine, population genetics, and immunology. ( Ned Tijdschr Geneeskd, 2002)
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Lederberg, J. Biological weapons
The Rockefeller University
Joshua Lederberg. Biological weapons: limiting the threat
Series: BCSIA studies in international security
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Levine, S. /Editor Coronary thrombosis
The Rockefeller University
Samuel A. Levine. Coronary thrombosis; its various clinical features
Series: Medicine monographs; v. 16
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Lloyd, D. The cell division cycle
The Rockefeller University
David Lloyd, Robert K. Poole, Steven W. Edwards/editors. The cell division cycle: temporal organization and control of cellular growth and reproduction
An appreciation of the basic control processes involved in cellular reproduction is central to investigations of factors leading to the defective stated in cancer and is therefore of great importance to cell biology in general. This book highlights the sequentially ordered processes that characterize the growth and division of a cell with particular emphasis on studies which concentrate on the dynamic aspects of these control systems.
Firstly, the time domain occupied by cell-cycle-dependent events is orientated with respect to biological reactions and events, and the oscillatory character of the cell cycle is illustrated. A description of the synthesis of cell components, including DNA, RNA, and proteins, leads to a discussion of the time course of the assembly of multicomponent structures, which also considers the organization of the energy supply for these biosynthetic events. There is a review of the invaluable information obtained from cell division cycle mutants, which under nonpermissive conditions cannot complete the natural cycle of events, and the book concludes with an analysis of the implications for the application of these researches to problems of cytodifferentiation and cancer therapy.
The book has almost two hundred figures and some 25000 references, mostly from the last ten years, and includes some unpublished work from the authors’ own laboratories. Thus research workers and postgraduates in biology, biochemistry, genetics and cell physiology will find this an up-to-date treatise on an important new aspect of cell research.
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Loeb, J. Artificial parthenogenesis and fertilization
The Rockefeller University
Jacques Loeb, W. O. Redman King. Artificial parthenogenesis and fertilization
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Loeb, J. Forced movements, tropisms, and animal conduct
The Rockefeller University
Jacques Loeb. Forced movements, tropisms, and animal conduct
Series: Monographs on experimental biology
The present volume is the first of a series of monographs on experimental biology to be written by American biologists under the general editorship of Jacques Loeb, T. H. Morgan, and W. J. V. Osterhout. It embodies the author's conceptions respecting the nature of animal conduct. As many biologists are aware, animal conduct was explained by this author on the tropism theory some thirty years ago. In the course of years, many extensions have been made to this theory by Loeb and others. The book gives a brief but clear-cut summary of the entire subject as it stands today.
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Loeb, J. Proteins and the theory of colloidal behavior
The Rockefeller University
Jacques Loeb. Proteins and the theory of colloidal behavior
Series: International chemical series
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Loeb, J. The mechanistic conception of life
The Rockefeller University
Jacques Loeb. The mechanistic conception of life; biological essays
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Loeb, J. The organism as a whole
The Rockefeller University
Jacques Loeb. The organism as a whole, from a physicochemical viewpoint
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Lorente de No, R. The primary acoustic nuclei
The Rockefeller University
Rafael Lorente de Nó. The primary acoustic nuclei
This monograph presents the results of the author’s research studies on the acoustic nuclei of the cat. It contains reproductions of more than 100 original drawings prepared from Golgi or Golgi-Cox sections, as well as microphotographs of 19 myelin-stained sections that present the locations of the various subdivisions of the acoustic nuclei and the courses of the main association tracts.
This volume, a classic contribution to the literature by one of the world’s outstanding neuroanatomists, will be an invaluable addition to the library of every neuroscientists and anatomist.
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Marler, P. Mechanisms of animal behavior
The Rockefeller University
Peter Marler, William J. Hamilton. Mechanisms of animal behavior
By unifying psychological, physiological and zoological viewpoints, this book provides a unique treatment of the mechanisms that control animal behavior. For example, social communication in animals are discussed in the light of knowledge of the physiological properties of different types of sense organs, as well as methods of orientation, navigation, and echolocation; the subject of behavioral development is given a fresh approach by emphasizing the interplay of genetic and environmental influences; and the temporal organization of sequences of behavior is given a new emphasis. In addition, the major viewpoints are placed in historical perspective to further clarify the principles of organization in animal behavior.
The authors draw many instructive examples from the behavior of vertebrate and invertebrate animals. They illustrate such diverse themes as circadian rhythms, the physiology of hunger and thirst, neural rhythms and locomotion, the role of external stimuli in behavioral control, the nature of exploratory behavior, aggression, and play.
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Mauro, A. Muscle regeneration
The Rockefeller University
Alexander Mauro/editor. Muscle regeneration
Papers presented at a conference held at Rockefeller University, Feb. 20-21, 1978
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McCarty, M. Streptococcal infections
The Rockefeller University
Maclyn McCarty/editor. Streptococcal infections: Symposium Held at the New York Academy of Medicine, 1953
Series: New York Academy of Medicine. The section on Microbiology. Symposia; no. 7
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McCarty, M. The transforming principle
The Rockefeller University
Maclyn. McCarty. The transforming principle: discovering that genes are made of DNA
Series: Commonwealth Fund Book Program
1st edition
Maclyn McCarty's The Transforming Principle is an elegantly written story of the discovery that DNA is hereditary material―perhaps the most important discovery in biology of the twentieth century. Also, it is the story of the scientists and the science which represents compelling reading for all science watchers." ―Paul A. Marks, M.D., president, Memorial Sloan-Kettering Cancer Center
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McEwen, B. /alt. author. Sexual differentiation of the brain
The Rockefeller University
Robert W. Goy, Bruce S. McEwen. Sexual differentiation of the brain: based on a work session of the Neurosciences Research Program
This book, based on a Work Session of MIT's Neurosciences Research Program, presents a balanced account of a controversial topic&-the relative importance of genes, hormones, and environment in the formation of sexual behavior.
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McEwen, B./editor. Neurotransmitters, hormones, and receptors
The Rockefeller University
James A. Ferrendelli, Bruce S. McEwen, Solomon H. Snyder/editors. Neurotransmitters, hormones, and receptors: novel approaches
Series: Neuroscience symposia ; v. 1
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McEwen, B. The end of stress as we know it
The Rockefeller University
Bruce S. McEwen, Elizabeth Norton Lasley. The end of stress as we know it
McEwen draws on extensive research, including his own, to explain the role of stress (or "allostatic load") in our lives and how to use it to good effect rather than be injured by it.
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McKean, H. Fourier series and integrals
The Rockefeller University
Harry Dym, Henry P. McKean. Fourier series and integrals
Series: Probability and mathematical statistics; v.14.
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McKean, H. Stochastic integrals
The Rockefeller University
Henry P. McKean. Stochastic integrals
Series: Probability and mathematical statistics; v. 5
This well-written book has been used for many years to learn about stochastic integrals. The book starts with the presentation of Brownian motion, then deals with stochastic integrals and differentials, including the famous Itô lemma. The rest of the book is devoted to various topics of stochastic integral equations, including those on smooth manifolds. -- E.B. Dynkin, Mathematical Reviews
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