Document Type

Article

Publication Date

2005

Keywords

cell maturationden, dritic cell, immunotherapy, lymphocyte, natural killer cell, vaccination, tumor

Abstract

Pathogen recognition by Toll-like receptors (TLRs) on dendritic cells (DCs) leads to DC maturation and the initiation of adaptive immunity. Recent studies have shown that innate lymphocytes-natural killer (NK), natural killer T (NKT), and γδT cells-also trigger DC maturation. This interaction in turn expands and activates innate lymphocytes and initiates adaptive T cell immunity. Here, we comment on the evidence that these pathways are TLR independent and have the potential to respond to infection, malignancy, and immunotherapy.cell maturationdendritic cell

Comments

Open Access

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