Document Type
Article
Publication Date
2005
Keywords
cell maturationden, dritic cell, immunotherapy, lymphocyte, natural killer cell, vaccination, tumor
Abstract
Pathogen recognition by Toll-like receptors (TLRs) on dendritic cells (DCs) leads to DC maturation and the initiation of adaptive immunity. Recent studies have shown that innate lymphocytes-natural killer (NK), natural killer T (NKT), and γδT cells-also trigger DC maturation. This interaction in turn expands and activates innate lymphocytes and initiates adaptive T cell immunity. Here, we comment on the evidence that these pathways are TLR independent and have the potential to respond to infection, malignancy, and immunotherapy.cell maturationdendritic cell
Recommended Citation
Münz, C., R. M. Steinman, and S. -I Fujii. 2005. "Dendritic Cell Maturation by Innate Lymphocytes: Coordinated Stimulation of Innate and Adaptive Immunity." Journal of Experimental Medicine 202 (2): 203-207
Comments
Open Access