Student Theses and Dissertations
Date of Award
1981
Document Type
Thesis
Degree Name
Doctor of Philosophy (PhD)
Thesis Advisor
Henry Kunkel
Keywords
immunoglobulins, B lineage, plasma cells, myeloma, antigen specificity, protein structure
Abstract
The specificity of the immune response to antigen was first appreciated by the study of serum immunoglobulins (Igs). The subpopulation of lymphoid cells that synthesize these molecules are so defined as members of the B lineage; the end-stage cell type of this lineage is the plasma cell. The acceptance, over the past thirty years, of myeloma proteins as normal products of plasma cells in clonal overgrowth (Kunkel, 1966) has provided both a homogeneous source for study and a paradigm. The structural characteristics of Igs which form the basis of specificity can now be, literally, seen in three dimensions; it is likely that all other antigen-reactive molecules, of different cell types in the system, will share similar structural characteristics.
License and Reuse Information
This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 International License.
Recommended Citation
McCune, Joseph M., "Biogenesis of Membrane-Bound and Secreted Immunoglobulins" (1981). Student Theses and Dissertations. 745.
https://digitalcommons.rockefeller.edu/student_theses_and_dissertations/745
Comments
A thesis presented to the faculty of The Rockefeller University in partial fulfillment of the requirements for the degree of Doctor of Philosophy