Studies on Delayed-Type Hypersensitivity Including Attempts to Effect Transfer in Guinea Pigs with Subcellular Materials

Author

Barry R. Bloom

Date of Award

1963

Document Type

Thesis

Degree Name

Doctor of Philosophy (PhD)

Abstract

The initial observation that delayed-type hypersensitivity could be transferred from an allergic to a normal animal by means of living white cells was made at The Rockefeller Institute many years ago. Since that time it has been recognized that cellular transfer appears to be a unifying principle underlying both contact dermatitis and tuberculin hypersensitivity. Later studies in man have suggested that the phenomenon can be reproduced with use cell-free extracts. Similar attempts have been made with extracts of cells from sensitized guinea pigs but, there exist only three reports in the literature which claim that transfer of contact or tuberculin hypersensitivity can be readily accomplished between animals (guinea pigs) by means of disrupted cells or subcellular materials.

Comments

A thesis submitted to the Faculty of The Rockefeller Institute in partial fulfillment of the requirements for the degree of Doctor of Philosophy

Recommended Citation

Bloom, Barry R., "Studies on Delayed-Type Hypersensitivity Including Attempts to Effect Transfer in Guinea Pigs with Subcellular Materials" (1963). Student Theses and Dissertations. 570.
https://digitalcommons.rockefeller.edu/student_theses_and_dissertations/570