Student Theses and Dissertations

Date of Award


Document Type


Degree Name

Doctor of Philosophy (PhD)


The order of addition of amino acids to a growing protein is determined by the codon sequence of a messenger RNA molecule. This translation process was studied in vitro with a cell-free protein synthesis system derived from Escherichia coli. The rate of protein synthesis was proportional to the amount of messenger RNA added to the system. However, it was observed that different messenger RNA's were not equally effective in promoting protein synthesis. Experiments were conducted to determine why the rate of protein synthesis depends on the type of messenger RNA.


A thesis submitted to the Faculty of The Rockefeller University in partial fulfillment of the requirements for the degree of Doctor of Philosophy

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Life Sciences Commons