Title
Preview
Creation Date
6-2018
Description
Blobel and Sabatini hypothesized in 1971 that a nascent peptide, bearing a terminal ‘signal’, interacts with a binding factor attached to the endoplasmic reticulum (ER) membrane, allowing docking of the ribosome and its associated mRNA. Upon passage of the newly synthesized protein across the ER membrane, the ribosome is able to dissociate from the site of synthesis and re-enter the cytoplasmic pool, ready for another round of synthesis
Blobel, G. and Sabatini, D. (1971) in Biomembranes, pp.193-195, Plenum Press, New York
Photo by Lubosh Stepanek
Keywords
Günter Blobel, David Sabatini