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Creation Date

4-2017

Description

Peter H. Sellers. On the theory and computation of evolutionary distances.

SIAM J. Appl. Math., 1974: 26(4)

Peter’s early work in sequence comparison is probably best encapsulated in three papers that take a mathematically rigorous approach to sequence alignment. In the first, published in the SIAM Journal on Applied Mathematics in 1974, he defines a distance measure between sequences, which he proves to be a metric, and he also describes and proves valid an algorithm for calculating it. This is, basically, what is today commonly known as the Needleman-Wunsch algorithm, although a careful reading of Saul B. Needleman and Christian D. Wunsch’s paper shows that they, in fact, describe a different algorithm. It is really Sellers’ algorithm or a related one by David Sankoff, that is currently used.

–Stephen Altschul, coauthor of the BLAST algorithm

Keywords

Peter Sellers, sequence comparison

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