Student Theses and Dissertations

Date of Award


Document Type


Degree Name

Doctor of Philosophy (PhD)

RU Laboratory

Edelman-Cunningham Laboratory


Cell-cell adhesion is one of the essential processes for normal embryogenesis. The isolation and characterization of the neural cell adhesion molecule, N-CAM, provided the first substantial opportunity to study this process at a molecular level. Moreover, studies of N-CAM expression in embryos suggested that cell adhesion molecules may play a critical role in induction. This thesis describes the isolation of a glycoprotein, L-CAM, that mediates adhesion between liver cells, using an assay similar to the one used to isolate N-CAM.


A thesis submitted to the Faculty of The Rockefeller University in partial fulfillment of the requirements for the degree of Doctor of Philosophy

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Life Sciences Commons