Student Theses and Dissertations

Date of Award


Document Type


Degree Name

Doctor of Philosophy (PhD)


A number of studies have demonstrated that small metabolites can react nonenzymatically with proteins to form covalent, addition products. An example of this type of reaction 1s the modification of hemoglobin A by glucose to form the minor species hemoglobin A1c. In this case, glucose reacts by forming a reversible Schiff base adduct with the N-terminal valine of the β -chain of hemoglobin. The Schiff base intermediate then slowly undergoes an Amadori rearrangement to produce a stable ketoamine addition product.


A thesis submitted to the Faculty of The Rockefeller University In partial fulfillment of the requirements for the degree of Doctor of Philosophy

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