The Nonenzymatic Modification of Proteins by Steroids and DNA by Reducing Sugars; In Vitro and In Vivo Studies

Author

Richard J. Bucala

Date of Award

1984

Document Type

Thesis

Degree Name

Doctor of Philosophy (PhD)

Abstract

A number of studies have demonstrated that small metabolites can react nonenzymatically with proteins to form covalent, addition products. An example of this type of reaction 1s the modification of hemoglobin A by glucose to form the minor species hemoglobin A_1c. In this case, glucose reacts by forming a reversible Schiff base adduct with the N-terminal valine of the β -chain of hemoglobin. The Schiff base intermediate then slowly undergoes an Amadori rearrangement to produce a stable ketoamine addition product.

Comments

A thesis submitted to the Faculty of The Rockefeller University In partial fulfillment of the requirements for the degree of Doctor of Philosophy

Recommended Citation

Bucala, Richard J., "The Nonenzymatic Modification of Proteins by Steroids and DNA by Reducing Sugars; In Vitro and In Vivo Studies" (1984). Student Theses and Dissertations. 585.
https://digitalcommons.rockefeller.edu/student_theses_and_dissertations/585