Recall Germinal Center and Antibody Responses

Author

Ariën Schiepers

Date of Award

2024

Document Type

Thesis

Degree Name

Doctor of Philosophy (PhD)

RU Laboratory

Victora Laboratory

Abstract

Repeated exposure to viruses or their antigens elicits anamnestic antibody responses that produce antibodies that are of greater magnitude and affinity compared to those induced after primary exposure to antigen.The anamnestic nature of the response is a result of the recall of memory Bcells (MBCs) that have undergone clonal expansion and affinity maturation in germinal centers(GCs) during the primary response. Upon antigen re-encounter (“boosting”), MBCs, aided by enhanced help from memory T cells, efficiently differentiate into antibody-secreting plasma cells.

Comments

A Thesis Presented to the Faculty of The Rockefeller University in Partial Fulfillment of the Requirements for the degree of Doctor of Philosophy

Recommended Citation

Schiepers, Ariën, "Recall Germinal Center and Antibody Responses" (2024). Student Theses and Dissertations. 777.
https://digitalcommons.rockefeller.edu/student_theses_and_dissertations/777