Structural Mechanisms of F-actin Mechanochemical Regulation and Flexible Network Assembly

Author

Matthew J. Reynolds

Date of Award

2024

Document Type

Thesis

Degree Name

Doctor of Philosophy (PhD)

RU Laboratory

Alushin Laboratory

Abstract

The actin cytoskeleton integrates physical and chemical cues from a cell’s environment to instruct its behavior, coordinating processes including cell migration, organelle dynamics, and endocytosis. Actin-binding proteins (ABPs) specify actin filament (F-actin) organization to build micron-scale networks which power these cell dynamics. Interactions between ABPs and F-actin are regulated by both biochemical processes and mechanical forces. The mechanisms mediating this interplay remain unclear at the protein structural level.

Comments

A Thesis Presented to the Faculty of The Rockefeller University in Partial Fulfillment of the Requirements for the degree of Doctor of Philosophy

Recommended Citation

Reynolds, Matthew J., "Structural Mechanisms of F-actin Mechanochemical Regulation and Flexible Network Assembly" (2024). Student Theses and Dissertations. 775.
https://digitalcommons.rockefeller.edu/student_theses_and_dissertations/775