Discovery and Optimization of a Family of Naturally Encoded Antibiotic Compounds that Evade Antibiotic

Author

Adam Rosenzweig

Date of Award

2024

Document Type

Thesis

Degree Name

Doctor of Philosophy (PhD)

RU Laboratory

Brady Laboratory

Abstract

Antibacterial resistant infections are an ongoing global health emergency. To combat this,novel potent antibiotics with unique modes of action are required. The classic arsenal of antibiotics used in clinical settings are largely natural products discovered by bulk fermentation of bacterial species isolates that are then extracted and purified to yield a bioactive compound.Unfortunately, this discovery pipeline no longer produces novel molecules, thus new discovery methodologies are essential to continue to identify antibiotic clinical candidate molecules. In the modern era, coupling natural product discovery with sequencing technologies has proven to bean efficient and fruitful method of identifying secondary metabolite natural products with unique bioactivity that could not previously be accessed through fermentation-based methods. This novel approach presents a promising reinvigoration to the field of antibiotics discovery.

Comments

A Thesis Presented to the Faculty of The Rockefeller University in Partial Fulfillment of the Requirements for the degree of Doctor of Philosophy

Recommended Citation

Rosenzweig, Adam, "Discovery and Optimization of a Family of Naturally Encoded Antibiotic Compounds that Evade Antibiotic" (2024). Student Theses and Dissertations. 774.
https://digitalcommons.rockefeller.edu/student_theses_and_dissertations/774