Document Type
Article
Publication Date
2011
Keywords
neuron dynamics, first passage problem, principle of sloppy workmanship
Abstract
We derive a model of a neuron's interspike interval probability density through analysis of the first passage problem. The fit of our expression to retinal ganglion cell laboratory data extracts three physiologically relevant parameters, with which our model yields input-output features that conform to laboratory results. Preliminary analysis suggests that under common circumstances, local circuitry readjusts these parameters with changes in firing rate and so endeavors to faithfully replicate an input signal. Further results suggest that the so-called principle of sloppy workmanship also plays a role in evolution's choice of these parameters.
Publisher
MIT Press
RU Laboratory
Knight Laboratory
Permanent URL
http://hdl.handle.net/10209/541
Recommended Citation
Sirovich, L. and Knight, B. (2011) Spiking Neurons and the First Passage Problem. Neural Comput. 23, 1675-1703.
Comments
Posted with permission: Copyright (2011), Massachusetts Institute of Technology. http://www.mitpressjournals.org/loi/neco