Student Theses and Dissertations

Date of Award


Document Type


Degree Name

Doctor of Philosophy (PhD)

RU Laboratory

Kapoor Laboratory


Cells utilize energy to maintain order within the cytoplasm. Motor proteins are the enzymes that convert the chemical energy contained in adenosine triphosphate (ATP) into directed movement along polarized filaments of actin and tubulin within cells. Dyneins are the primary enzymes that drive motion toward the stable “minus ends” of tubulin-containing filaments known as microtubules. This protein family is divided into two sub-families. Axonemal dyneins drive flagellar beating while cytoplasmic dyneins (hereafter, dyneins) are required a wide array of cellular processes including moving RNAs, proteins, and whole organelles and for the formation, maintenance, and positioning of the mitotic spindle, the protein apparatus that ensures proper cell division.


A Thesis Presented to the Faculty of The Rockefeller University in Partial Fulfillment of the Requirements for the degree of Doctor of Philosophy

Included in

Life Sciences Commons