Date of Award
Doctor of Philosophy (PhD)
Cells utilize energy to maintain order within the cytoplasm. Motor proteins are the enzymes that convert the chemical energy contained in adenosine triphosphate (ATP) into directed movement along polarized filaments of actin and tubulin within cells. Dyneins are the primary enzymes that drive motion toward the stable “minus ends” of tubulin-containing filaments known as microtubules. This protein family is divided into two sub-families. Axonemal dyneins drive flagellar beating while cytoplasmic dyneins (hereafter, dyneins) are required a wide array of cellular processes including moving RNAs, proteins, and whole organelles and for the formation, maintenance, and positioning of the mitotic spindle, the protein apparatus that ensures proper cell division.
Steinman, Jonathan Baruch, "Chemical Approaches to Dynein Inhibition" (2018). Student Theses and Dissertations. 482.