Krause, R./Editor Antibodies in human diagnosis and therapy
Edgar Haber, Richard M. Kraus/editors. Antibodies in human diagnosis and therapy
The purpose of this volume is to provide a summary of the current state of knowledge of the structure of the antigen combining site, approaches to the synthesis of antibodies by chemical and biological means, and their application in human therapy. The covalent structure of the antibody combining site is analyzed in relation to the specificity of the antigen which it binds. The available three-dimensional models of combining sites are presented showing detailed mechanisms of antigen binding at an atomic level. The concept of the chemical synthesis of antibodies is critically addressed and evaluated as a potential future method for the manufacture of antibodies for therapeutic and diagnostic use.
The authors of this volume include fundamental investigators in the field of immunoglobulin structure, X-ray crystallographers, peptide synthetic chemists, cellular immunologists, and clinical investigators. They combine their diverse interests to give the reader a fascinating glimpse into an exciting and rapidly developing field.
antibodies, immunoglobulins, immunotherapy
The Rockefeller University, "Krause, R./Editor Antibodies in human diagnosis and therapy" (1975). RU Authors. 88.