Transfer of proteins across membranes. Manuscript with Palade's correction
Blobel’s most influential papers were published together with his postdoctoral fellow Bernhard Dobberstein in 1975 in The Journal of Cell Biology. These papers established that N-terminal signal sequences direct nascent secretory proteins across the endoplasmic reticulum membrane, an idea previously proposed by Blobel and David D. Sabatini in 1971, with first experimental evidence provided by César Milstein and colleagues in 1972. The Blobel and Dobberstein papers rigorously showed that a secretory protein is co-translationally translocated across the membrane and that the signal sequence subsequently was cleaved off.
Günter Blobel, Bernhard Dobberstein, George Palade, The Journal of Cell Biology