The sequence of amino acid residues in oxidized bovine ribonuclease
In 1959, the Moore-Stein laboratory succeeded in working out the first complete description of the chemical structure of an enzyme and the largest protein to decoded up to that time. The enzyme they deciphered was pancreatic ribonucleic acid (RNA). They found that ribonuclease consists of a chain of 124 amino acids comprising 1876 atoms. They identified the amino acids and demonstrated how they fit together in the ribonuclease molecule.
amino acid, ribonuclease, Stanford Moore, William Stein